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 Release 24.0, April 2009
 
Chapter : ch32. Clinical Pharmacology & Toxicology Section : Pharmacologic and Pharmacokinetic Terms
  Mean Residence Time

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Overview :

The mean residence time is the average time that molecules of a drug reside in the body after a dose.

 

mean residence time in hours =

= 1.44 * (half-life in hour) =

= (volume of distribution in L) / (clearance in L per hr)

 

half-life for the drug in hours =

= (mean residence time) / 1.44 = 0.693 * (mean residence time)

 

  References:

Rowland M, Tozer TN. Clinical Pharmacokinetics - Concepts and Applications. Third Edition. Williams and Wilkins. 1995. pages 70 and 485.

 

 

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