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 Release 21.0, Jan 2008
 
Chapter : ch27. Oncology: Non-Hematologic Section : Patient Screening for Malignancy
  When to Consider the Diagnosis of a Familial or Hereditary Cancer

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Copyright (c) 2006-2007, Institute for Algorithmic Medicine, Houston, TX, USA. All rights reserved.

Overview :

The possibility of a familial or hereditary cancer should be considered in a patient with certain clinical features.

 

A hereditary or familial disorder be considered if one or more of the following is present:

(1) diagnosis of cancer at an unusually early age

(2) multiple primary tumors arising simultaneously in the same organ

(3) bilateral development of primary tumors in a paired organ

(4) 2 or more primary tumors in the same individual

(5) presence of a close relative with the same or a related tumor

(6) high rate of cancer in a family

(7) presence of congenital anomalies or birth defects

(8) forebears from a genetic group with a high rate of hereditary disorders such as Ashkenazi Jews

(9) family is known to have a specific genetic mutation or disorder

 

Problems that may limit the evaluation:

(1) absence of a familial history because of adoption

(2) problems with paternity

(3) no surviving relatives available for testing

(4) errors or incompleteness of clinical information provided by relatives (ancestry, diagnosis, etc.)

(5) errors or incompleteness in the medical record

 

  References:

Petersen GM, Codori A-M. Chapter 49: Genetic testing for familial cancer. pages 1063-1076 (page 1069, with list of internet resources in Table 49-2 on pages 1070-1071). IN: Scriver CR, Beaudet AL, et al (editors). The Metabolic and Molecular Bases of Inherited Disease, Eighth Edition. McGraw-Hill. 2001.

 

 

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