|
Overview :
Ray-Coquard et al developed model for identifying adults
with cancer who required blood transfusion following chemotherapy. The authors
are members of the ELYPSE 1 Study Group from Lyon, Villejuif, Chambery, Neuilly
and Toulouse, France.
Patient selection: age >= 18 years of age, solid tumor
and receiving chemotherapy
Endpoint: Severe anemia requiring blood transfusion within
31 days of chemotherapy
Parameters at start of chemotherapy:
(1) ECOG performance scale
(2) hemoglobin
(3) absolute lymphocyte count
|
Parameter
|
Finding
|
Points
|
|
ECOG performance scale
|
0 or 1
|
0
|
|
|
2, 3 or 4
|
1
|
|
hemoglobin
|
>= 12 g/dL
|
0
|
|
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< 12 g/dL
|
3
|
|
absolute lymphocyte count (ALC)
|
> 700 per µL
|
0
|
|
|
<= 700 per µL
|
1
|
total risk score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum risk score: 0
• maximum risk score: 3
|
Number of Risk Factors
|
Percent Requiring RBC Transfusion
|
|
0
|
1.2%
|
|
1
|
3.8%
|
|
2 or 3
|
11%
|
|
4 or 5
|
30%
|
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