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 Release 22.0, Sept. 2008
 
Chapter : ch45. Pharmacy Practice Section : Writing and Filling a Prescription
  Dispensing Sufficient Oseltamivir to Treat a Patient for Influenza

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Copyright (c) 2008-2010, Institute for Algorithmic Medicine, Houston, TX, USA. All rights reserved.

Overview :

Osetlamivir (Tamiflu) is an oral drug that can be used to treat or prevent influenza A or B. Sufficient drug needs to be dispensed to provide for the prescription.

 

NOTE: Determining the drug regimen for oseltamivir is discussed in 25.10.05.

 

Dosing forms:

(1) 75 mg capsules

(2) oral pediatric suspension with 12 mg/mL (25 mL with 300 mg)

 

The suspension outdates in 10 days after reconstitution.

 

Factors determining amount dispensed:

(1) dosing form (capsule or liquid suspension)

(2) size of dose (75 mg or based on patient weight)

(3) number of doses per day (1 or 2) or once every other day (used for prophylaxis when the creatinine clearance is 10-30 mL per minute)

(4) number of days received

(4a) 5 days for treatment

(4b) 7 days to 6+ weeks for prophylaxis

 

Dosing in children:

(1) by the table below (from the PDR)

(2) 2 mg per kg up to a maximum of 75 mg

(3) for prophylaxis in child >= 13 years, one 75 mg capsule

 

Pediatric Body Weight

Dose

Volume Suspension

<= 15 kg

30 mg

2.5 mL

15.01 to 23 kg

45 mg

3.75 mL

23.01 to 40 kg

60 mg

5.0 mL

> 40 kg

75 mg

6.25 mL

 

number of 75 capsules to dispense =

= (number of doses per day) * (number of days to treat)

 

volume of drug suspension to dispense in mL =

= (dose in mg) * (number of doses per day) * (number of days to treat) / 12

 

number of bottles of drug suspension to dispense =

= (dose in mg) * (number of doses per day) * (number of days to treat) / 300

 

  References:

Gilbert DN, Moellering RC Jr, et al. The Sanford Guide to Antimicrobial Therapy, 34th Edition. 2004.

Gravenstein S, Davidson HE. Current strategies for management of influenza in the elderly population. Clin Infect Dis (CID). 2002; 35: 729-737.

Thomson PDR. Physicians' Desk Reference (PDR), 57 Edition. 2003. page 2933

 

 

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