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 Release 22.0, Sept. 2008
 
The Medical Algorithms Project
Chapter : ch45. Pharmacy Practice Section : Writing and Filling a Prescription
  Dispensing the Appropriate Capsule Combination for the Daily Dose of Temozolomide

  Online Excel Reference
Copyright (c) 2008-2010, Institute for Algorithmic Medicine, Houston, TX, USA. All rights reserved.

Overview :

Temozolomide (brandname Temodar, Schering) is a chemotherapeutic agent used in the therapy of high grade astrocytoma. A series of capsules are dispensed to meet the prescribed daily dose. Proper dispensing is essential to prevent overdosage with excessive toxicity.

 

Dosage regimens for each cycle:

(1) initial: 150 mg per square meter BSA per day x 5 days

(2) subsequent: 200 mg per square meter BSA per day x 5 days

 

Capsule sizes:

(1) 5 mg

(2) 20 mg

(3) 100 mg

(4) 250 mg

 

Daily Dose in milligrams

250 mg

100 mg

20 mg

5 mg

200

0

2

0

0

205

0

2

0

1

210

0

2

0

2

215

0

2

0

3

220

0

2

1

0

225

0

2

1

1

230

0

2

1

2

235

0

2

1

3

240

0

2

2

0

245

0

2

2

1

250

1

0

0

0

255

1

0

0

1

260

1

0

0

2

265

1

0

0

3

270

1

0

1

0

275

1

0

1

1

280

1

0

1

2

285

1

0

1

3

290

1

0

2

0

295

1

0

2

1

300

0

3

0

0

305

0

3

0

1

310

0

3

0

2

315

0

3

0

3

320

0

3

1

0

325

0

3

1

1

330

1

0

4

0

335

1

0

4

1

340

0

3

2

0

345

0

3

2

1

350

1

1

0

0

355

1

1

0

1

360

1

1

0

2

365

1

1

0

3

370

1

1

1

0

375

1

1

1

1

380

1

1

1

2

385

1

1

1

3

390

1

1

2

0

395

1

1

2

1

400

0

4

0

0

405

0

4

0

1

410

0

4

0

2

415

0

4

0

3

420

0

4

1

0

425

0

4

1

1

430

1

1

4

0

435

0

4

1

3

440

0

4

2

0

445

0

4

2

1

450

1

2

0

0

455

1

2

0

1

460

1

2

0

2

465

1

2