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 Release 22.0, Sept. 2008
 
Chapter : ch39. Decisional Analysis Section : Performance Measures
  Negative Predictive Value (NPV)

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Overview :

The negative predictive value is the true-negative test results divided by all patients with negative results. This is also referred to as the  predictive value of a negative test.

 

negative predictive value =

= (d / (c + d))

 

where:

• d =  true negatives

• (c + d) = sum of ( false negatives and true negatives) = all negative test results

 

If the prevalence of disease in a study is similar to that in the population [prevalence in the population = (a + c) / (a + b + c + d)], then the probability of disease with a negative result is (c / (c + d)), or (1 - NPV).

 

  References:

Braunwald E, Isselbacher KJ, et al (editors). Harrison's Principles of Internal Medicine, 11th edition. McGraw-Hill Book Publishers. 1987. page 7

Goldman L. Chapter 10: Quantitative aspects of clinical reasoning. pages 43-48. IN: Isselbacher KJ, Braunwald E, et al. Harrison's Principles of Internal Medicine, Thirteenth Edition. McGraw-Hill. 1994.

Panzer RJ, Black ER, Griner PF. Interpretation of diagnostic tests and strategies for their use in quantitative decision making. pages 17-28. IN: Panzer RJ, Black ER, et al. Diagnostic Strategies for Common Medical Problems. American College of Physicians. 1991.

Speicher C, Smith JW Jr.. Choosing Effective Laboratory Tests. WB Saunders. 1983. pages 50-51, and 210

 

 

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