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Overview :
The negative predictive value is the true-negative test
results divided by all patients with negative results. This is also referred to
as the predictive value of a negative
test.
negative predictive value =
= (d / (c + d))
where:
• d = true negatives
• (c + d) = sum
of ( false negatives and true negatives) = all negative test results
If the prevalence of disease in a study is similar to that
in the population [prevalence in the population = (a + c) / (a + b + c + d)],
then the probability of disease with a negative result is (c / (c + d)), or (1
- NPV).
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Braunwald E,
Isselbacher KJ, et al (editors). Harrison's
Principles of Internal Medicine, 11th edition. McGraw-Hill Book Publishers.
1987. page 7
Goldman L.
Chapter 10: Quantitative aspects of clinical reasoning. pages 43-48. IN:
Isselbacher KJ, Braunwald E, et al. Harrison's
Principles of Internal Medicine, Thirteenth Edition. McGraw-Hill. 1994.
Panzer RJ,
Black ER, Griner PF. Interpretation of diagnostic tests and strategies for
their use in quantitative decision making. pages 17-28. IN: Panzer RJ, Black
ER, et al. Diagnostic Strategies for Common Medical Problems. American College
of Physicians. 1991.
Speicher C, Smith
JW Jr.. Choosing Effective Laboratory Tests. WB Saunders. 1983. pages 50-51,
and 210
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