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Overview :
Smith et al described risk categories for children with
acute lymphoblastic leukemia (ALL). This can help determine the treatment
regimen to use. The authors are from the Natioanl Cancer Institute (NCI).
Parameters at initial diagnosis:
(1) age of the patient in years
(2) white blood cell count (WBC)
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Age in Years
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Initial WBC Count
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Risk Group
|
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< 1 year
|
NA
|
high risk
|
|
1 - 9 years
|
> 50,000 per µL
|
high risk
|
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1 - 9 years
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<= 50,000 per µL
|
standard risk
|
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>= 10 years of
age
|
NA
|
high risk
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Whitlock et al found that children in the standard risk
group had a decreased event-free survival if they:
(1) had Down syndrome
(2) were Asian
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