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 Release 21.0, Jan 2008
 
The Medical Algorithms Project
Chapter : ch25. Antibiotics, Vaccines & Prophylaxis Section : Interpretation of Antibiotic Susceptibility Testing
  Fractional Bactericidal Concentration (FBC)

  Excel Sheet Reference
Copyright (c) 2006-2007, Institute for Algorithmic Medicine, Houston, TX, USA. All rights reserved.

Overview :

The fractional bactericidal concentration is an interaction coefficient indicating whether the combined bactericidal effect of drugs is synergistic, additive or antagonistic.

 

fractional bactericidal concentration =

= A + B

 

where:

• A = (MBC of combination X + Y) / (MBC of drug X alone)

• B = (MBC of combination X + Y) / (MBC of drug Y alone)

 

  References:

Jacobs D, Demott W, et al. Laboratory Test Handbook, 3rd edition. Lexi-Comp Inc. Hudson, Ohio. 1994. page 869

Jacobs D, Demott W, et al. Laboratory Test Handbook, 4th edition. Lexi-Comp Inc. Hudson, Ohio. 1996. page 449-450.

 

 
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