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 Release 21.0, Jan 2008
 
Chapter : ch23. Microbiology & Infectious Diseases Section : Evaluation of Bacteremias and Sepsis
  Index for Predicting Bacteremia or Occult Bacterial Infection in Adults with Acute Unexplained Fever

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Overview :

An index can be used to identify those adults with acute, unexplained fever who have bacteremia or an occult bacterial infection.

 

Patients studied:

• 926 patients 16 years of age or older during 11 months from 1982 to 1983

• oral or rectal temperature >= 37.9°C (100.2°F) for less than 3 weeks duration

• examined at Yale-New Haven Hospital Emergency Department by internists

 

Parameters found associated with bacteremia or occult bacterial infection:

(1) age

(2) presence of diabetes mellitus

(3) erythrocyte sedimentation rate (Wintrobe)

(4) white blood cell count

(5) neutrophil band count

 

Parameter

Finding

Points

age

>= 50 years of age

1

 

< 50 years of age

0

diabetes mellitus

present

1

 

absent

0

erythrocyte sedimentation rate

>= 30 mm/h

1

 

< 30 mm/h

0

white blood cell count

>= 15,000 per µL

1

 

< 15,000 per µL

0

neutrophil band count

>= 1,500 per µL

1

 

< 1,500 per µL

0

 

index =

= SUM(points for parameters present)

 

Interpretation:

• minimum score: 0

• maximum score: 5

 

Index

% with Bacteremia

% with Bacteremia or Focal Infection

0

0%

5%

1

7%

33%

2

16%

39%

3 - 5

39%

55%

 

Additional insights during study:

• Appearing seriously ill can be seen in patients without bacterial infection.

• Some patients with bacteremia may not appear sufficiently ill to warrant hospitalization.

• An initial temperature >= 39.4°C (103°F) was not predictive of occult bacterial infection.

 

  References:

Mellors JW, Horwitz RI, et al. A simple index to identify occult bacterial infection in adults with acute unexplained fever. Arch Intern Med. 1987; 147: 666-671.

 

 

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