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Overview :
Agarwal et al developed 2 semen quality scores for
evaluating men with infertility. This uses parameters determined by computer
assisted semen analysis. The authors are from The Cleveland Clinic Foundation.
Parameters:
(1) sperm
concentration as a multiple of 10^6 per mL
(2) percent
motility (from 0 to 100)
(3) percent
normal using strict morphology usingTygerberg criteria (Mortimer and Menkveld,
from 0 to 100)
(4) percent
normal using WHO morphology (from 0 to 100)
(5) curvilinear
velocity in micrometers per second (µm/s)
(6) straight
line velocity in micrometers per second (µm/s)
(7) average
path velocity in micrometers per second (µm/s)
(8) linearity
in percent (enter from 0 to 100)
(9) amplitude
of lateral head displacement in micrometers (µm)
where:
• The
curvilinear velocity is the time-averaged velocity of the sperm head along its
actual curvilinear path.
• The straight
line velocity is the time-averaged velocity of the sperm head along the
straight line between its first detected position and its last.
• The average
path velocity is the time-averaged
velocity of the sperm head along its average path.
• The linearity
of curvilinear path = (VSL) / (VCL) * 100%
• The amplitude
of lateral head displacement is magnitude of lateral displacement of a sperm
head about its average path.
overall semen quality SQ score =
= (((0.807647 * (LOG10(sperm concentration + 1))) +
(0.254114 * (LOG10(percent motility + 1))) + (0.331027 * (LOG10(percent normal
Tygerberg + 1))) + (0.274769 * (LOG10(percent normal WHO + 1))) + (0.146286 *
(LOG10(curvilinear velocity + 1))) + (0.193481 * (LOG10(straight line velocity
+ 1))) + (0.175990 * (LOG10(average path velocity + 1))) + (0.009109 *
(LOG10(linearity + 1))) + (0.090307 * (LOG10(amplitude of lateral head
displacement + 1)))) * 34.46018) - 20.1911369
relative semen quality RQ score =
= (((-0.567457 * (LOG10(sperm concentration + 1))) +
(0.147947* (LOG10(percent motility + 1))) + (0.605335 * (LOG10(percent normal Tygerberg
+ 1))) + (0.418694 * (LOG10(percent normal WHO + 1))) + (0.180399 *
(LOG10(curvilinear velocity + 1))) + (0.202853 * (LOG10(straight line velocity
+ 1))) + (0.1891590 * (LOG10(average path velocity + 1))) + (0.009502 *
(LOG10(linearity + 1))) + (0.069321 * (LOG10(amplitude of lateral head
displacement + 1)))) * 55.1448) + 24.5183708
where:
• A "1" was added to all of the raw values (page
344). The arguments given escape me.
• 34.46018 = 10 / (0.29019)
• 55.1448 = 10 / (0.1813407)
Interpretation:
• The SQ score
is the sum of all semen characteristics with varying weights for each
parameter. The SQ score decreases as the number of abnormal features increases.
• The SQ score
for a normal person ranges from 100 to 120.
• The RQ score
is the relative quality, with negative weighting for concentration and positive
weighting for the other 8 parameters. The highest RQ score would be for a
specimen with a low sperm concentration and the other features above average.
• The RQ score
for a normal person ranges from 100 to 120.
• The scores
from before and after an intervention can be compared to determine if an
improvement has occurred.
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