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 Release 21.0, Jan 2008
 
The Medical Algorithms Project
Chapter : ch14. Renal & Urinary System Section : Creatinine Clearance and Excretion
  Creatinine Clearance & Degree of Renal Impairment

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Copyright (c) 2006-2007, Institute for Algorithmic Medicine, Houston, TX, USA. All rights reserved.

Overview :

Creatinine clearance overestimates the GFR. The overestimation is greater in renal disease and when "true" methods are used.

 

Renal Status

Cr Cl mL/min

normal (males)

90 - 130

normal (females)

80 - 125

slight

52 - 62.5

mild impairment

42 - 52

moderate impairment

28 - 42

severe impairment

< 28

anuric

0

from page 655, Wallach (1996); Newkirk (1978);

 

 

Renal Status

Cr Cl mL/min

normal

> 80

mild impairment

50 - 79

moderate impairment

10 - 49

severe impairment

< 10

anuric

0

from: Table 1, Jackson and McLeod (1974)

 

 

renal function (as % normal)

turnover time (hours) of creatinine

half-life (hours) of creatinine

100

6

4

50

12

8

33

18

12

25

24

17

20

30

21

10

60

42

from Table 23-2, page 432, Rowland (1995)

 

  References:

Jackson EA, McLeod DC. Pharmacokinetics and dosing of antimicrobial agents in renal impairment, part I. Amer J Hosp Pharm. 1974; 31:36-52

Newkirk R, Rawnsley H, ASCP Clinical Chemistry Check Sample CC-110 (1978)

Rowland M, Tozer TN. Clinical Pharmacokinetics - Concepts and Applications. Third Edition. Williams and Wilkins. 1995

Wallach J. Interpretation of Laboratory Tests, 6th edition. Little Brown and Company. 1996. pages 655-658.

 

 
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