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Overview :
Creatinine dynamics can be estimated by assessing urine and
serum. Typically a 24 hour urine is used for the study.
creatinine clearance (mL/min) =
= ((urine creatinine in mg/dL) * (urine volume in mL)) /
((plasma creatinine in mg/dL) * (time period in minutes))
where:
• 24 hours = 1440 minutes
Limitations:
• It is assumed
that the patient has relatively stable creatinine dynamics over the time period
studied. Some patients can have fluctuating renal function sufficient to
interfere with the evaluation.
• Although
shorter periods of time than 24 hours can be used if needed, if the period is
too short, then misleading information can be derived.
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