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Overview :
Acute hypervitaminosis A can occur after 1 or more high doses
of vitamin A.
Risk factors:
(1) high dose of vitamin A (100,000 units of retinol or
more)
(2) decreased serum retinol-binding protein (protein
malnutrition, liver disease)
General findings:
(1) anorexia
(2) drowsiness
(3) irritability
(4) nausea and vomiting
(5) increased intracranial pressure with headache and
papilledema, pseudotumor cerebri
(6) skin desquamation, exfoliative dermatitis
Findings seen in infants:
(1) bulging fontanelle
Findings seen in adults:
(1) abdominal pain
(2) blurred vision (due to papilledema)
(3) muscle weakness
(4) peripheral neuritis
Laboratory findings:
(1) elevated serum vitamin A
Concurrent findings:
(1) hypervitaminosis D (if vitamin D present in vitamin
preparation)
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