|
Overview :
Sadowski et al evaluated the ability of serum chemistry
tests to identify patients with acute pancreatitis secondary to gallstones. The
authors are from the University
of Calgary and Foothills Hospital in Calgary, Alberta, Canada.
Parameters:
(1) serum alkaline phosphatase
(2) serum AST (SGOT)
(3) serum total bilirubin
|
Parameter
|
Finding
|
Points
|
|
serum alkaline phosphatase
|
< 115 IU/L
|
0
|
|
|
>= 115 IU/L
|
1
|
|
serum AST
|
< 80 IU/L
|
0
|
|
|
>= 80 IU/L
|
1
|
|
serum total bilirubin
|
< 15 µmol/L
|
0
|
|
|
>= 15 µmol/L
|
1
|
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
|
Total Score
|
Observed Sensitivity
|
Observed Specificity
|
|
1
|
95%
|
46%
|
|
2 or 3
|
82%
|
79%
|
|
3
|
55%
|
90%
|
Based on the Youden index, a score >= 2 showed optimum
performance.
The presence of an elevated AST alone had a diagnostic
efficiency of 80%.
Limitations:
• The analysis
was performed on a Kodak Ektachem. The reference ranges for the 3 tests was not
given. This means that transporting the method may require some adjustments to
the cutoff points.
|